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doi: 10.1371/journal.pbio.0050177 586 DecodeME

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MOTS-c and retatrutide differences Comparison Compound type Retatrutide Investigational triple-receptor agonist MOTS-c Mitochondrial-derived peptide Comparison Main research focus Retatrutide Appetite, energy balance, and metabolic outcomes MOTS-c Cellular energy signaling and mitochondrial function Comparison Human evidence Retatrutide Larger controlled clinical program MOTS-c Limited native-peptide human evidence Comparison Typical schedule discussed Retatrutide Weekly MOTS-c Several days per week in community protocols Comparison Interchangeable

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