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Together, these findings underscore riboflavin’s dual neuroprotective role: inhibiting pro-inflammatory signaling at the cellular level, and reinforcing BBB stability to reduce neuroinflammatory propagation

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The identified oxylipins were assigned to five subgroups, namely cyclooxygenase (COX)-dependent derivatives of AA (PGD2, PGE2, PGF2α, TXB2), cytochrome p450 (CYP)-dependent derivatives of LA (9,10-DiHOME/9,10-EpOME and 12,13-DiHOME/12,13-EpOME), as well as lipoxygenase (LOX)-dependent derivatives of AA (5-HETE, 12-HETE, and LTB4), LA (9-HODE/9-KODE and 13-HODE/13-KODE) and ALA (9-HOTrE, 13-HOTrE)