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Similarly, amino acid metabolism influences Treg differentiation because glutamine deprivation promotes Treg polarization even under strong Th1 polarizing conditions (146), while loss of amino acid transporters Sic7a5 or Sic1a5 impairs Th1, Th2 and Th17 differentiation without affecting Tregs (104)

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Together these papers extend the tesamorelin literature past the original lipodystrophy framing into modern HIV care and into outcomes beyond fat distribution alone