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Pm-ME (0–400 μg mL −1 ) significantly reduced tyrosinase activity at concentrations above 200 μg mL −1

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Capsule count:60 Capsules

Interestingly, reduced expression of enzymes involved in FA transport and β-oxidation was paralleled by substantial modifications in PPARs, a family of FA-activated nuclear receptors, with attenuated expression of Pparα and Pparγ and a dramatic increase in Pparβ/δ expression in cKOt mice (Supplemental Figure 6)