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Across GLP-1 trials, about 60% of lost weight returns within the first year and roughly 75% returns over the longer curve, with the fastest regain in the early months.²¹ The semaglutide extension follows the same direction.⁶ The pattern reflects removal of appetite suppression after major weight loss

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The most common patient complaints are minor: soreness at injection site, a transient headache, or mild diarrhea