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Moreover, non-protein-bound iron may also increase the activity of iron-containing enzymes such as prolyl hydroxylase (PHD)—Dependent proteasomal system 23 , which plays a key role in the degradation of hypoxia-inducible factor-1 alpha (HIF-1α) 24

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Our research uses decade-based age groups, a specific categorization based on clinical experience and the typical age-related distribution patterns observed in the progression of lumbar disc degeneration

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