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Moreover, loss of JAM-A resulted in elevated mucosal and serum immunoglobulin A that was dependent on CD4(+) T cells and tumor growth factor-β

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27 Medical conditions in which heavy metal ion excess promotes oxidative stress include iron overload (hemochromatosis or hemosiderosis), copper overload (Wilson’s disease), and heavy metal poisoning (Hg, Pb, Ni, Se, etc.)