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Immunological safety profiling of AOD-9604 indicates a very low incidence of hypersensitivity reactions or systemic allergic responses, though rare instances of mild cutaneous rashes, localized urticaria, or low-titer antibody generation have been documented following chronic, high-dose exposure in complex experimental models, emphasizing the critical importance of utilizing ultra-pure, HPLC-verified material and adhering strictly to established dosing guidelines to minimize any risk of immunogenic sensitization or adverse inflammatory cascades