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SCFA producing Lachnospiraceae and Ruminococcaceae were reduced in US combat veterans with cirrhosis and PTSD compared to those without PTSD, together with increased pathobionts Enterococcus and Escherichia/Shigella ( Dialister, Eubacterium ) and increased pro-inflammatory pathobionts ( Collinsella, Veillonella ) compared to controls, along with increased nitrate reductase-associated metabolites linked to nitrogen metabolism pathways

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21 Chronic alcohol ingestion, however, augments APAP hepatotoxicity by up-regulating, enhancing and increasing the synthesis and activity of CYP 2E1 and decreasing GSH stores and synthesis, thus enhancing liver necrosis and worsening prognosis