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A patient may suspect histamine intolerance when symptoms track with certain foods, but the same symptoms can overlap with food allergy, celiac disease, inflammatory bowel disease, irritable bowel syndrome, medication reactions, hormone changes, thyroid disease, post-viral syndromes, dysautonomia, or MCAS
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While nausea, vomiting, and diarrhea commonly occur with tirzepatide—particularly during dose escalation—severe symptoms may require dose adjustment, temporary treatment interruption, or additional supportive care